Topographic Evolution and Climate Aridification during Continental Collision: Insights from Computer Simulations

Topographic Evolution and Climate Aridification during Continental Collision: Insights from Computer Simulations

How do the feedbacks between tectonics, sediment transport and climate work to shape the topographic evolution of the Earth? This question has been widely addressed via numerical models constrained with thermochronological and geomorphological data at scales ranging from local to orogenic. Here we present a novel numerical model that aims at reproducing the interaction between these processes a...

Salinity and Climate Reconstructions from Continental Lakes

Cytoskeletal mechanics of neurulation: insights obtained from computer simulations.

The morphogenetic movements associated with the process of neurulation have been the subject of much investigation during the last one hundred years. A plethora of experimental evidence has been generated regarding the forces that drive this seemingly simple process, and many theories about the mechanics of the process have been proposed. Recent computer simulations have proved useful for evalu...

Can We Trust the Transgenic Mouse? Insights from Computer Simulations

Over the past several decades, the mouse has gained prominence in the cardiac electrophysiology literature as the animal model of choice. Using computer models of the mouse and human ECG, this paper is a step toward understandingwhen themouse succeeds and fails tomimic functional changes resulting from disease states and drug interactions.

Computer simulations of prebiotic evolution.

This paper is a review of our previous work on the field of possible ways of prebiotic evolution. We propose an algorithm providing sequences of model proteins with rapid folding into a given native conformation. Thermodynamical analysis shows that the increase in speed is matched by an increase in stability: the evolved sequences are much more stable in their native conformation than the initi...